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Verapamil

Calcium Channel Blockers⁠

Leave a Comment / Cardiology, Top 200 Drugs /
CCB1
CCB2
CCB3
CCB4
CCB5

💊 Calcium channel blockers (CCBs) are used in the treatment of many cardiovascular conditions including hypertension and angina so needless to say they easily make the top 200 drugs prescribed.⁠⠀
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👉🏻 They are divided into subclasses, non-dihydropyridines, and dihydropyridines and differ by their pharmacokinetic properties, clinical uses, response, and selectivity. ⁠⠀
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👉🏻 Dihydropyridine CCBs end in the suffix ‘-ine’: ⁠⠀
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-AmlodipINE⁠⠀
-NicardipINE⁠⠀
-NifedipINE⁠⠀
-NimodipINE⁠⠀
-FelodipINE⁠⠀
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👉🏻 Non-dihydropyridine CCBs don’t end in the suffix ‘-ine’ hinted by the name of the subclass, NOn-dihydropyridINE:⁠⠀
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-Verapamil⁠⠀
-Diltiazem⁠⠀
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Calcium Channel Blockers⁠ Read More »

CYP450 Enzymes, Major Inhibitors of

Leave a Comment / Miscellaneous /
The CYP450 enzymes are essential for the production of numerous agents including cholesterol and steroids. Additionally, these enzymes are necessary for the detoxification of foreign chemicals and the metabolism of drugs.⁠ ⁠ Drugs that are CYP450 inhibitors block the metabolic activity of one or more of the CYP450 enzymes. The extent to which an inhibitor affects the metabolism of a drug depends upon factors such as the dose and the ability of the inhibitor to bind to the enzyme.⁠

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Calcium Channel Blockers

Leave a Comment / Cardiology, Top 200 Drugs /
Calcium channel blockers (CCBs) are used in the treatment of many cardiovascular conditions. They are divided into subclasses, non-dihydropyridines and dihydropyridines. The non-dihydropyridine CCBs cause less vasodilation and more cardiac depression than dihydropyridine CCBs (hence why they are not recommended in decompensated heart failure). They cause reductions in heart rate and contractility. Dihydropyridine CCBs have more vascular selectivity and fewer cardiac effects. They are indicated in the treatment of hypertension and angina. They do not suppress AV conduction or the SA node automaticity.

Calcium Channel Blockers Read More »

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