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Diuretics Sites of Action

Diuretics work to enhance sodium and water excretion through 4 main sites on the nephron.

1– Proximal convoluted tubule: Mannitol and acetazolamide (extends into the descending loop of Henle)

2– Ascending loop of Henle: loop diuretics

3– Distal convoluted tubule: thiazides

4– Collecting ducts: Potassium-sparing diuretic (e.g., spironolactone and triamterene)