pharma fact
Corticosteroid Side Effects
Ever been on corticosteroids before? Due to the activation of the sympathetic system (“fight or flight”), your body responds with an increase in blood pressure, blood sugar, mood changes, and blood volume. With short term use, side effects are minor but can vary depending on their dose and how long they are taken.
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Diuretics Sites of Action
Diuretics work to enhance sodium and water excretion through 4 main sites on the nephron.
1– Proximal convoluted tubule: Mannitol and acetazolamide (extends into the descending loop of Henle)
2– Ascending loop of Henle: loop diuretics
3– Distal convoluted tubule: thiazides
4– Collecting ducts: Potassium-sparing diuretic (e.g., spironolactone and triamterene)
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Insulin Analogs
👉🏻 Insulin Analogs are available for insulin replacement therapy.
👉🏻 Insulins also are classified by the timing of their action in your body – specifically, how quickly they start to act, when they have a maximal effect and how long they act.
Phenytoin Side Effects
Phenytoin has a narrow therapeutic window (10-20 mg/L) and requires serum drug monitoring to prevent toxicities. Check out this awesome mnemonic on how to remember its side effects!
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