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CYP450

CYP450 Enzymes, Major Inducers of

๐Ÿ‘‰๐Ÿป Drugs that are inducers increase CYP450 enzyme activity by increasing enzyme synthesis. โ  โ  ๐Ÿ‘‰๐Ÿป A drug also may be metabolized by the same CYP450 enzyme that it induces. Carbamazepine (Tegretol), a potent enzyme inducer, must be initiated at a low dose and then increased at weekly intervals as its half-life gradually decreases over time.โ 

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CYP450 Enzymes, Major Inhibitors of

The CYP450 enzymes are essential for the production of numerous agents including cholesterol and steroids. Additionally, these enzymes are necessary for the detoxification of foreign chemicals and the metabolism of drugs.โ  โ  Drugs that are CYP450 inhibitors block the metabolic activity of one or more of the CYP450 enzymes. The extent to which an inhibitor affects the metabolism of a drug depends upon factors such as the dose and the ability of the inhibitor to bind to the enzyme.โ 

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