Tricyclic Antidepressant (TCAs) Side Effects
Tricyclic antidepressants (TCAs) are drugs used to treat depression, bipolar disorder, and other conditions such as chronic pain and insomnia. They primarily work by blocking norepinephrine and serotonin (5HT2) reuptake. They also block acetylcholine and histamine receptors which contribute to their side effect profile.โ
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๐๐ป Muscarinic M1 block: anticholinergic side effects including dry mouth, blurry vision, constipation, and urinary retentionโ
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๐๐ป Histamine 1 receptor block: sedation and weight gainโ
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๐๐ป Adrenergic alpha block: postural hypotension, tachycardia, and erectile disfunction โ
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๐๐ป Sodium channel block: QTc prolongation, arrhythmias โ
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๐๐ป Serotonin uptake block: weight gainโ