Aminoglycosides – ‘The 3 Amigos’â
â
â AMINOglycosides are antibiotics comprised of AMINO acid sugars that are linked together. â
â
3ïžâŁ The three most commonly used are (mnemonic: TAG): â
-Tobramycinâ
-Amikacinâ
-Gentamicinâ
â
Other agents include plazomicin, streptomycin, and neomycin. â
â
â They are used for serious infections caused by gram-negative bacteria such as complicated UTIs, sepsis, or intraabdominal infections. They can also be used in combination with other agents for infectious caused by gram-positive bacteria in endocarditis. â
â
â MOA: they kill bacteria by binding onto 30S ribosomal subunits inhibiting the bacteriaâs ability to synthesize proteins, leading to cell deathâ
â
â Other key facts to know:â
-Adverse effects include nephrotoxicity and ototoxicityâ
-They are approximately 70-95% excreted renallyâ
-They are concentration-dependent bacterial killers, which means bacterial killing increases with rising drug concentrationsâ
-Monitor serum drug levels (troughs and peaks), serum creatinine, BUN, urine output, and hearingâ .